Dell
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casein-cancer (was Thanksgiving dinner) - 2006/06/07 04:49
<snip>
The link is unproven. So are links between casein and nearly every other disease. It appears casein is a scapegoat for everything from autism to cancer to senility to ADD-ADHD for those who write (and read) pseudo-scientific literature. Yet repeated studies haven't borne links between casein and such diseases.
Consider the following. A study comparing mice fed soy, whey, and casein (control group) diets had some interesting findings. The mice were induced by chemical (DMBA) to have mammary tumors. When 100% of the casein-fed rats had at least one tumor, soy-fed rats had a lower tumor incidence (77%) in experiment B (P < 0.002), but NOT in experiment A (P < 0.12), and there were NO differences in tumor multiplicity. Whey-fed rats had lower mammary tumor incidence (54–62%; P < 0.002) and multiplicity (P < 0.007) than casein-fed rats in both experiments. Our results indicate that diets rich in soy reduce the incidence of chemically induced mammary tumors by approximately 20%. Furthermore, whey appears to be at least twice as effective as soy in reducing both tumor incidence and multiplicity.
[my emphasis for experiment A] http://cebp.aacrjournals.org/cgi/content/abstract/9/1/113
So at least one component of dairy (whey) seems to be quite beneficial, at least with DMBA-induced tumors. Note that casein is typically used as a control protein. From the discussion section of the full article: Studies involving dietary prevention of tumors often use casein as the "control" protein source and compare all dietary effects to the results of groups fed casein. One possibility not often discussed is that casein-fed rats could be at greater risk of developing DMBA-induced mammary tumors than rats fed diets containing whey or soy protein isolate. If that were true, our data would suggest that factors in casein and soy protein isolate could promote tumor formation compared with whey. This is an area requiring further research.
That doesn't mean that casein-fed rats would grow more tumors absent the presence of DMBA. It's still important to note the researchers' comparison of casein *and soy* to whey -- and soy may well prove to be more problematic than casein. We already know soy can speed tumor multiplicity in some types of cancer. Another study has found that "Genistein [phytoestrogen from soy protein isolate] was effective in reducing tumor multiplicity, but it reduced tumor incidence only marginally. Daidzein [the other soy phytoestrogen] was less effective in reducing both tumor incidence and multiplicity." Soy has also been linked to certain kinds of cancer, including bladder cancer.
First source (phytoestrogens and breast cancer): http://www.lef.org/prod_hp/abstracts/php-ab325a.html#59
Second souce (bladder cancer study): http://tinyurl.com/w76v
I agree with the study team above that more research is needed, but doctors who state that "casein causes cancer" are making unscientific claims until such findings are made from studies.
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